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Updated: May 4, 2026

Viral Tracing of Genetically Defined Neural Circuitry
Published on: October 17, 2012
Reovirus type 2 isolated from cerebrospinal fluid
Laura Hermann1, Joanne Embree, Paul Hazelton
1Department of Medical Microbiology and Infectious Disease, University of Manitoba, 511-730 William Avenue, Winnipeg, Manitoba R3E 0W3, Canada.
Abstract:
An 8-week-old female infant presented with a history of active varicella complicated by Escherichia coli sepsis, oral thrush, hypoalbuminemia, intermittent fevers, diarrhea and feeding intolerance. Rhesus monkey kidney cells inoculated with cerebrospinal fluid revealed reovirus-like particles by electron microscopy. Virus neutralization and RNA-gel electrophoresis studies identified the isolated pathogen as reovirus serotype 2. This report represents one of only a few to isolate reovirus from the central nervous system in humans.
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