[Effects of Gu Chi paste on PGE(2) in periodontitis tissues of guinea pigs]

OBJECTIVE: Study the effects of Gu Chi paste on PGE(2) in gingiva and alveolar bone and its mechanism to treating periodontitis. METHODS: Periodontitis were formed with silk thread suture and high sugar diet,fed guinea pigs on Gu Chi paste and indomethacin.The prostaglandin E(2)(PGE(2)) in gingiva and alveolar bone were measured with radioimmunoassay (RIA). RESULTS: The Gingival Index(GI) and Pocket Deep(PD) of group Periodontitis (PE) were bigger than group Normal(N),the alveolar bone absorbed more severe,the PGE(2) level in gingiva and alveolar bone in PE was higherthan that in N.The GI and PD of group Gu Chi paste(Gu) were lower than that of PE,its alveolar bone absorbed more slight.There were more significant difference of PGE(2) in alveolar bone between Gu and group indomethacin(IND).The PGE(2) level of Gu in gingiva were similar as that of IND. CONCUSION: Gu Chi paste can inhibite the formation of experimental periodontitis and the contents of PGE(2) in gingiva and alveolar bone,and the effect on PGE(2) in alveolar was more severe. The mechanism of Gu Chi paste to periodontitis has inhibitory effects on PGE(2) in gingiva and alveolar bone.