[A test of interleukin 2(IL-2) and T-cell subpopulation in patients with head and neck carcinomas]

OBJECTIVE:Serum levels of interleukin 2(IL-2) and peripheral blood T-cell subpopulation were measured in 35 patients with head and neck carcinomas.The results indicated that the pro-operative patients' CD8(+) was significantly higher,while the IL-2 level and CD4(+)/CD8(+) were greatly lower than that of controls (P<0.01),and CD4(+)was no significant difference.They were closely related with clinical stage.After operation,the CD8(+)decreated(P<0.01) and the serum IL-2 level,CD4(+)/CD8(+) elevated(p<0.01).It indicated that patients with head and neck carcinomas presented obvious abnormality of celluar immunological function.So,combined analysis of serum IL-2 and T-cell subpopulation may be useful to evaluate patients' immunological condition and to make up therapeutic plan.