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Updated: Aug 24, 2026

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
09:21

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

[Fragile histidine triad expression in rhabdomyosarcoma]

Shou-li Wang1, Guang-hua Yang, Hong Bu

  • 1Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.

Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition
|April 10, 2004
PubMed
Abstract

Insights

Reduced expression of the fragile histidine triad (FHIT) protein is common in rhabdomyosarcoma (RMS). This finding suggests FHIT may be a new prognostic marker for RMS progression, including metastasis.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Context:

  • Rhabdomyosarcoma (RMS) is a pediatric soft tissue sarcoma.
  • The role of the fragile histidine triad (FHIT) tumor suppressor in RMS pathogenesis is not fully understood.

Purpose:

  • To investigate the expression levels of FHIT protein in RMS tissues.
  • To explore the potential mechanisms and prognostic significance of FHIT in RMS.

Summary:

  • Immunohistochemistry revealed significantly reduced FHIT expression in 68.2% of RMS cases compared to 35% in normal skeletal muscle.
  • FHIT expression did not correlate with patient sex, tumor histology, or grade.
  • However, reduced FHIT expression was significantly associated with tumor relapse and metastasis.

Impact:

  • Reduced FHIT expression is implicated in the development and progression of RMS.
  • FHIT may serve as a novel biomarker for predicting RMS prognosis and outcomes.

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