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[Protective effect of berberine on cardiac hypertrophy induced by L-thyroxine in rats]
Jing Yang1, Zu-yu Zhou, Jian-guo Xu
1Department of Physiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Objective:
To assess the effects of berberine on cardiac hypertrophy induceded by L-thyroxine(L-Thy) in rats.
Methods:
A cardiac hypertrophy model was produced by intraperitoneal (i.p.) injection of L-thyroxine 0.5 mg/(kg.d) x 10 d. 24 SD rats were divided into three groups: 1. control (normal saline); 2. L-Thy; 3. i.p. L-Thy + berberine gastrogavage 30 mg/(kg.d) x 10 d. Then the cardiac indexes, Na(+)-K(+)-ATPase activity, Ca(2+)-ATPase activity, the cardiac nitric oxide (NO) content, and the CaN activity were measured.
Results:
Compared with the measurements in the control group, the cardiac indexes and the CaN activity were remarkably increased in the hypertrophy group (P < 0.01), but the cardiac NO content, Na(+)-K(+)-ATPase activity and Ca(2+)-ATPase activity in myocardium were significantly decreased (P < 0.01). Further comparison between the hypertrophy group and the L-Thy + berberine group showed that berberine 30 mg/(kg.d) x 10 d prevented the ventricular hypertrophy induced by L-Thy and decreased the cardiac indexes and CaN activity (P < 0.01); berberine elevated the cardiac NO content, Na(+)-K(+)-ATPase activity and Ca(2+)-ATPase activity (P < 0.01).
Conclusion:
Berberine can prevent the cardiac hypertrophy induced by L-thyroxine in rats.
