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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
[Preparation of nifidipine pulsatile release tablets]
1Department of Pharmacy, Daping Hospital, Third Military University of Medical Sciences, Chongqing 400042, China.
Summary
This study developed nifedipine (NFP) bi-layered pulsatile release tablets. Formulation adjustments optimize drug release for chronotherapy, demonstrating a versatile drug delivery mechanism.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Materials Science
Context:
- Pulsatile drug delivery systems are crucial for chronotherapy, enabling targeted drug release at specific times.
- Nifedipine (NFP), a widely used cardiovascular drug, often requires controlled release to optimize therapeutic efficacy and minimize side effects.
- Existing formulations may not adequately address the temporal release needs for certain conditions.
Purpose:
- To formulate and characterize nifedipine (NFP) bi-layered pulsatile release tablets.
- To investigate the influence of formulation variables (coating level, osmotic agent, swelling layer) on NFP release kinetics.
- To determine the drug release mechanism and its independence from dissolution medium conditions.
Summary:
- Bi-layered pulsatile tablets of nifedipine (NFP) were successfully prepared using direct compression and spray coating techniques.
- Lag-time and release rate were modulated by adjusting the semipermeable membrane coating level and the concentration of osmotic active agent and swelling layer.
- Drug release was consistent across different pH values and rotation speeds, indicating a robust formulation.
Impact:
- The developed pulsatile release system offers a viable approach for nifedipine chronotherapy, potentially improving patient outcomes.
- The formulation strategy is adaptable for other water-insoluble drugs requiring pulsatile release.
- Understanding the combined diffusion, swelling, and osmotic pumping mechanisms provides a foundation for designing advanced drug delivery systems.
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