Related Experiment Video
Updated: Aug 24, 2026

A High-content Assay for Monitoring AMPA Receptor Trafficking
Published on: January 28, 2019
Neurotrophic effects of AMPA
1Dipartimento di Fisiologia Umana e Farmacologia, Università di Roma La Sapienza, Rome, Italy. cristina.limatola@uniroma1.it
Abstract:
AMPA-type glutamate receptors may transduce both neurotoxic and neurotrophic signals, basically depending on receptor subunit composition and on the extent of receptor activation. While a great deal of data are available on the mechanisms underlying the neurotoxic effects induced by AMPA receptor stimulation, much less is known about the molecular mechanisms responsible for their neurotrophic activities. This review describes the experimental evidences in favor of a neurotrophic effect of AMPA and compares the mechanisms identified and the signaling pathways involved with those relevant for the neurotrophic activities of other neurotrophins.
Related Concept Videos
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Long-term Potentiation
Hebbian LTP
LTP can occur when presynaptic neurons...
Long-term Potentiation
Enzyme-linked Receptors
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Excitatory and Inhibitory Effects of Neurotransmitters
Neurochemical Transmission: Sites of Drug Action
