Related Experiment Video

Updated: Aug 24, 2026

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
11:02

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

Expression of the cyclin-dependent kinase inhibitor p27 in transitional cell bladder cancers: is it a good predictor

Latife Doganay1, Semsi Altaner, Selcuk Bilgi

  • 1Department of Pathology, Trakya University Medical Faculty, Edirne, Turkey. lcdoganay@hotmail.com

International Urology and Nephrology
|April 10, 2004
PubMed
Abstract

Insights

p27 protein levels do not predict outcomes in bladder cancer. This study found no significant relationship between p27 expression and tumor characteristics or patient survival in transitional cell carcinoma.

Area of Science:

  • Oncology
  • Cell Biology
  • Cancer Research

Background:

  • Cell cycle progression is tightly regulated by cyclins, cyclin-dependent kinases (CDKs), and CDK inhibitors (CDKIs).
  • p27 is a key cyclin-dependent kinase inhibitor (CDKI) whose expression often decreases in developing tumors.
  • While p27 is a proposed prognostic factor in many cancers, its role in bladder cancer remains unclear.

Purpose of the Study:

  • To examine the immunohistochemical expression of p27 in transitional cell bladder cancers.
  • To correlate p27 expression with clinicopathological features, PCNA, and p53 immunoreactivity.

Main Methods:

  • Immunohistochemistry was used to analyze p27 expression in 75 paraffin-embedded transitional cell carcinoma specimens.
  • p27 expression was statistically compared with tumor grade, stage, growth pattern, disease-free survival, progression, PCNA, and p53.

Main Results:

  • p27 protein expression showed no significant association with clinicopathological parameters.
  • No significant correlation was found between p27 expression and disease-free survival, tumor progression, PCNA, or p53 immunoreactivity.

Conclusions:

  • p27 protein expression is not a reliable predictor of outcomes in transitional cell carcinoma of the bladder.
  • Further research may be needed to identify robust prognostic markers for bladder cancer.

Related Concept Videos

Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...