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Tuberculous orchiepididymitis diagnosed by nucleic acid amplification test: a case report
Zvonimir Barisić1, Neven Vrsalović-Carević, Kazimir Milostić
1Department of Microbiology, Public Health Institute, Split, Croatia. zbarisic@mamef.mef.hr
International Urology and Nephrology
|April 10, 2004
Summary
Tuberculous orchiepididymitis, a rare condition, was diagnosed using molecular methods when traditional tests failed. Prompt antitubercular therapy led to complete recovery, highlighting the importance of advanced diagnostics for this infection.
Area of Science:
- Urology
- Infectious Diseases
- Molecular Diagnostics
Background:
- Tuberculous orchiepididymitis is an uncommon manifestation of tuberculosis.
- Diagnosis can be challenging due to non-specific symptoms and negative conventional tests.
Observation:
- A 39-year-old male presented with scrotal swelling and fistula, unresponsive to antibiotics.
- Histopathology suggested tuberculosis, but bacteriology was negative.
- Molecular detection of Mycobacterium tuberculosis DNA in wound exudate confirmed the diagnosis.
Findings:
- Surgical intervention was followed by molecular confirmation of tuberculous etiology.
- Antitubercular therapy resulted in complete resolution of the inflammatory process.
- This case underscores the diagnostic utility of molecular methods in challenging cases.
Implications:
- Molecular diagnostics are crucial for confirming tuberculous orchiepididymitis when standard methods are inconclusive.
- Early and accurate diagnosis facilitates timely and effective antitubercular treatment.
- This case highlights the need to consider tuberculosis in refractory scrotal infections.