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Chitosan microspheres as a potential carrier for drugs
V R Sinha1, A K Singla, S Wadhawan
1University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India. vr_sinha@yahoo.com
International Journal of Pharmaceutics
|April 10, 2004
Summary
Chitosan, a natural polymer, offers excellent properties for drug delivery systems. This review explores its use in microencapsulation for improved drug dissolution and controlled release.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Pharmaceutical Technology
Background:
- Chitosan is a biodegradable, biocompatible polymer with mucoadhesive properties.
- It enhances the dissolution of poorly soluble drugs and influences fat metabolism.
- Chitosan's gelling ability enables applications in coating and entrapment.
Purpose of the Study:
- To review the utilization of chitosan properties for drug microencapsulation.
- To discuss various methods for preparing chitosan microspheres.
- To examine factors influencing drug entrapment and release kinetics.
Main Methods:
- Literature review on chitosan-based drug delivery systems.
- Analysis of techniques for chitosan microsphere preparation.
- Evaluation of factors affecting drug loading and release profiles.
Main Results:
- Chitosan microspheres are effective for encapsulating various drugs.
- Preparation techniques influence microsphere characteristics and drug loading.
- Entrapment efficiency and release kinetics are dependent on formulation parameters.
Conclusions:
- Chitosan is a versatile biomaterial for developing advanced drug delivery systems.
- Understanding preparation and formulation factors is crucial for optimizing chitosan microspheres.
- Further research can enhance chitosan's role in pharmaceutical applications.