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Updated: Aug 24, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Changes in fat and lean body mass during androgen-deprivation therapy for prostate cancer
1Division of Hematology-Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Objectives:
To assess the effects of androgen deprivation therapy on body composition in men with nonmetastatic prostate cancer.
Methods:
In a multicenter study, men with Stage M0 prostate cancer were prospectively evaluated during initial androgen deprivation therapy (gonadotropin-releasing hormone agonist or bilateral orchiectomy). The main outcomes were changes in weight, percentage fat mass, and percentage lean mass from baseline to 12 months.
Results:
Seventy-nine subjects were assessed. Serum testosterone concentrations decreased by 79.7% +/- 3.0% (P <0.001). Weight increased by 1.8% +/- 0.5% (P <0.001). The percentage fat mass increased by 11.0% +/- 1.7%, and the percentage lean mass decreased by 3.8% +/- 0.6% (P <0.001 for each comparison).
Conclusions:
Androgen deprivation therapy increased weight and fat mass and decreased lean mass in men with nonmetastatic prostate cancer.
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