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Receptor-mediated Endocytosis01:38

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Updated: Jul 1, 2026

Tractable Mammalian Cell Infections with Protozoan-primed Bacteria
13:54

Tractable Mammalian Cell Infections with Protozoan-primed Bacteria

Published on: April 2, 2013

How viruses enter animal cells.

Alicia E Smith1, Ari Helenius

  • 1Institute of Biochemistry, Swiss Federal Institute of Technology-Zurich, CH-8093 Zurich, Switzerland.

Science (New York, N.Y.)
|April 10, 2004
PubMed
Summary
This summary is machine-generated.

Viruses use host cell machinery to replicate. Animal viruses exploit cellular pathways, relying on cell cues for entry, transport, and uncoating into the host.

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Published on: September 10, 2021

Area of Science:

  • Virology
  • Cell Biology
  • Molecular Biology

Background:

  • Viruses are obligate intracellular parasites that depend on host cell machinery for replication.
  • Viral entry into host cells is a critical step for infection, involving complex interactions between viral and cellular components.
  • Understanding viral entry mechanisms is crucial for developing antiviral strategies.

Purpose of the Study:

  • To elucidate the mechanisms by which viruses gain access to host cells.
  • To investigate the role of cellular pathways in viral internalization and uncoating.
  • To identify critical cues provided by the host cell during viral entry.

Main Methods:

  • Analysis of viral entry pathways, focusing on endocytosis.
  • Investigation of molecular transformations viruses undergo during internalization.
  • Study of intracellular transport and uncoating processes mediated by cellular factors.

Main Results:

  • Viruses have evolved sophisticated mechanisms to deliver genetic material and proteins into host cells.
  • Many animal viruses utilize endocytic pathways for entry.
  • Host cell cues are essential for guiding viruses through entry, transport, and uncoating.

Conclusions:

  • Viral entry is a highly regulated process involving a dynamic interplay between virus and host cell.
  • The host cell actively participates in facilitating viral internalization and subsequent uncoating.
  • Targeting host-cell-mediated viral entry pathways presents a potential strategy for antiviral therapies.