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Updated: Aug 2, 2026

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
Published on: February 7, 2015
Race-specific relationships between coronary and carotid artery calcification and carotid intimal medial thickness
Lynne E Wagenknecht1, Carl D Langefeld, J Jeffrey Carr
1Department of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157-1063, USA. lwgnkcht@wfubmc.edu
Background And Purpose:
Calcified arterial plaque has been proposed as a subclinical marker of atherosclerosis. We compared it to a well-validated surrogate--carotid intimal medial thickness (IMT).
Methods:
Calcified arterial plaque was measured in 2 vascular beds (coronary and carotid) by computed tomography, and common carotid artery IMT was measured by B-mode ultrasonography, in 438 participants.
Results:
Calcium was positively associated with IMT (r=0.36 for coronary and r=0.45 for carotid, both P<0.0001). Correlations were attenuated with adjustment for age, sex, and diabetes.
Conclusions:
Calcified plaque in the coronary and carotid arteries is moderately associated with subclinical atherosclerosis.
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