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Related Experiment Videos

Hemostatic function and progressing ischemic stroke: D-dimer predicts early clinical progression.

Mark Barber1, Peter Langhorne, Ann Rumley

  • 1University Section of Clinical Gerontology and Vascular Medicine, Royal Infirmary, Glasgow, UK. M.Barber@clinmed.gla.ac.uk

Stroke
|April 10, 2004
PubMed
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Progressing ischemic stroke involves increased coagulation. Higher D-dimer levels indicate a higher risk of stroke progression, suggesting potential benefits from hemostatic interventions.

Area of Science:

  • Neuroscience
  • Hematology
  • Clinical Medicine

Background:

  • Early clinical progression in ischemic stroke is common, increasing risks of death and dependency.
  • Activation of the coagulation system is a suspected contributor to stroke deterioration.
  • Characterizing hemostatic markers in progressing stroke is crucial for understanding disease mechanisms.

Purpose of the Study:

  • To investigate alterations in circulating hemostatic markers in patients experiencing progressing ischemic stroke.
  • To identify specific markers associated with stroke deterioration.
  • To explore the role of the coagulation system in ischemic stroke progression.

Main Methods:

  • Recruitment of consecutive acute ischemic stroke admissions.
  • Definition of progressing stroke based on Scandinavian Stroke Scale deterioration.

Related Experiment Videos

  • Measurement of hemostatic markers including prothrombin fragments 1+2 (F1+2), thrombin-antithrombin complexes (TAT), D-dimer, and von Willebrand factor (vWF) within 24 hours.

    • Main Results:

    • Progressing stroke was observed in 25% of patients (54/219).
    • Elevated levels of F1+2, TAT, D-dimer, and vWF were found in patients with progressing stroke compared to stable patients.
    • Logistic regression identified natural log D-dimer and mean arterial blood pressure as independent predictors of stroke progression.

    Conclusions:

    • Evidence suggests increased thrombin generation and fibrin turnover in progressing ischemic stroke.
    • D-dimer levels are a valuable tool for identifying patients at high risk of stroke progression.
    • Further research is needed to evaluate the efficacy of hemostatic interventions in these patients.