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Polymyositis and hepatitis concurrent with breast cancer
Deniz Yamac1, Nazan Gunel, Berna Goker
1Department of Medical Oncology, Gazi University Medical School, Ankara, Turkey. dyamac@gazi.edu.tr
Summary
This case study details a rare instance of breast cancer linked to inflammatory muscle and liver disease, suggesting a paraneoplastic syndrome. Treatment of these conditions correlated with the cancer
Area of Science:
- Oncology
- Neurology
- Hepatology
Background:
- Breast cancer can present with rare paraneoplastic syndromes.
- Paraneoplastic syndromes involve autoimmune responses triggered by cancer, affecting distant organs.
Observation:
- A patient with breast cancer developed proximal muscle weakness and elevated liver enzymes.
- Liver biopsy showed hepatitis, and muscle biopsy revealed myositis.
Findings:
- Corticosteroid therapy improved myopathic symptoms and hepatitis.
- The paraneoplastic symptoms of polymyositis and hepatitis recurred with malignancy relapse.
Implications:
- This case highlights the potential for breast cancer to induce polymyositis and hepatitis as paraneoplastic manifestations.
- The findings support a paraneoplastic mechanism, where cancer triggers autoimmune inflammatory conditions.