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Related Experiment Videos

Bladder dysfunction during the use of tramadol.

R H Meyboom1, C C Brodie-Meijer, W L Diemont

  • 1Netherlands Pharmacovigilance Foundation LAREB, MH's-Hertogenbosch, The Netherlands.

Pharmacoepidemiology and Drug Safety
|April 10, 2004
PubMed
Summary

Tramadol use may cause temporary urinary retention in some patients. Symptoms resolved after discontinuing the medication, suggesting a link between tramadol and micturition issues.

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Area of Science:

  • Pharmacovigilance
  • Clinical Pharmacology
  • Urology

Background:

  • Tramadol is a widely used analgesic.
  • Urinary retention is not a commonly reported side effect of tramadol.
  • Opioid agonists can affect bladder function.

Purpose of the Study:

  • To report cases of suspected tramadol-induced urinary retention.
  • To investigate the association between tramadol use and micturition disturbances.

Main Methods:

  • Review of spontaneous case reports submitted to a pharmacovigilance center.
  • Analysis of patient demographics, tramadol dosage, and symptom onset/resolution.
  • Comparison with existing product information.

Main Results:

Related Experiment Videos

  • Five cases of transient urinary retention were reported in association with tramadol use.
  • Symptoms occurred at therapeutic doses (≤150 mg daily) and resolved upon drug cessation.
  • No prior mention of micturition disturbance in tramadol product characteristics.

Conclusions:

  • Tramadol may cause transient urinary retention, particularly in susceptible individuals.
  • Healthcare providers should be aware of this potential adverse effect.
  • Further investigation into tramadol's effects on bladder function is warranted.