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Updated: Jul 28, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Lamotrigine and severe skin eruptions.

J G Donahue¹, S E Andrade, E M Cain

¹Channing Laboratory, Brigham and Women's Hospital, Boston, MA 02115, USA. jim.donahue@channing.harvard.edu

Pharmacoepidemiology and Drug Safety

|April 10, 2004

Summary

This study found no evidence linking lamotrigine to severe skin reactions in children treated for seizure disorders. While the drug is important, further research is needed to fully assess its safety profile.

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Area of Science:

Pharmacology
Pediatric Neurology
Dermatology

Background:

Lamotrigine is a key medication for seizure disorders.
Reports suggest a concerning incidence of severe skin reactions in pediatric patients using lamotrigine.
This necessitates a thorough safety evaluation, particularly in children.

Purpose of the Study:

To investigate the association between lamotrigine exposure and severe skin reactions in children.
To determine if lamotrigine use is causally linked to adverse dermatological events in pediatric populations.

Main Methods:

Retrospective cohort study utilizing automated data from three Health Maintenance Organizations (HMOs).
Inclusion criteria: Children under 15 years old exposed to lamotrigine between January 1, 1995, and June 30, 1997.
Outcome assessment focused on hospitalizations for severe skin reactions, such as erythema multiforme.

Main Results:

Lamotrigine was dispensed to 124 children (mean age 8.7 years; 56% female).
Hospitalization occurred in 47% of exposed children, primarily for convulsions and epilepsy.
No hospitalizations were recorded for or with a diagnosis of severe skin reactions.

Conclusions:

The study found no evidence to support a causal relationship between lamotrigine and severe skin reactions in the studied pediatric cohort.
The small sample size limits the power to detect weaker associations, indicating that this study alone cannot definitively establish lamotrigine's risks.
These findings contribute to the overall evidence base for assessing the safety of lamotrigine in children.