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Hormonal and genetic determinants of bone loss in community-dwelling elderly men: a longitudinal population study
S Goemaere1, I van Pottelbergh, J M Kaufman
1Unit for Osteoporosis and Metabolic Bone Diseases, Department of Internal Medicine, Ghent University Hospital, De Pintelaan 185-B 9000 Gent.
Abstract:
In community-dwelling elderly men over age 70 years, BioE2 was positively associated with prospectively assessed BMD changes over 4 years. The CYP19 (TTTA)n-repeat polymorphism was, moreover, an additional independent determinant of BMD changes at the distal forearm. Furthermore, the CYP19 genotype was associated with self-reported clinical fracture status. The present analyses add further evidence to the view that serum BioE2 is a determinant of bone mass in elderly men and provides an indication that the aromatase enzyme may exert a direct modulatory action on bone metabolism at the tissue level in ageing men.
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