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[Quality of life in elderly patients with ischemic cardiopathy]

Giuseppe M C Rosano1, Cristiana Vitale, Daniela Onorati

  • 1Unità di Ricerca Cardiovascolare, Dipartimento di Scienze Mediche, San Raffaele-Tosinvest Sanità, Roma. giuseppe.rosano@sanraffaele.it

Italian Heart Journal : Official Journal of the Italian Federation of Cardiology
|April 13, 2004
PubMed

Insights

Adjunctive trimetazidine therapy improves cardiac performance, reducing angina symptoms and enhancing quality of life for elderly patients with ischemic heart disease. This metabolic agent offers a valuable addition to standard care.

Area of Science:

  • Cardiology
  • Geriatrics
  • Pharmacology

Context:

  • Aging populations experience increased cardiovascular disease incidence, impacting elderly health and quality of life.
  • Ischemic heart disease management in older adults requires consideration of comorbidities and therapy's effect on longevity and well-being.
  • Revascularization is indicated for refractory angina or when symptoms severely impair quality of life.

Purpose:

  • To evaluate the utility of metabolic agents, specifically trimetazidine, as adjunctive therapy in elderly patients with ischemic heart disease.
  • To assess the impact of trimetazidine on angina symptoms, cardiac performance, and quality of life in this demographic.

Summary:

  • Conventional antianginal drugs can cause adverse effects in the elderly due to altered pharmacokinetics and hemodynamic actions.
  • Adjunctive trimetazidine therapy demonstrated improved cardiac global performance in elderly patients with ischemic heart disease.
  • This improvement correlated with reduced angina symptoms, enhanced functional capacity, and better quality of life.

Impact:

  • Adjunctive trimetazidine offers a potentially safer and more effective treatment option for angina in elderly patients.
  • Metabolic therapy with trimetazidine may improve overall patient outcomes and well-being in geriatric cardiovascular care.
  • This approach highlights the importance of considering metabolic modulation alongside traditional hemodynamic therapies for ischemic heart disease.

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