Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Islet transplantation: an update.

Jyuhn-Huarng Juang1

  • 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei. jjuang@cgmh.org.tw

Chang Gung Medical Journal
|April 13, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Exendin-4 on the Differentiation and Function of Transplanted Porcine Neonatal Pancreatic Cell Clusters in Diabetic Nude Mice.

Journal of diabetes research·2025
Same author

A Mobile Health Intervention for Improving Problem-Solving Skills, Emotional Adaptation, and Glycemic Control in Patients With Type 2 Diabetes.

Research in nursing & health·2025
Same author

Empagliflozin Reduces High Glucose-Induced Cardiomyopathy in hiPSC-Derived Cardiomyocytes : Glucose-induced Lipotoxicity in hiPSC-Derived Cardiomyocytes.

Stem cell reviews and reports·2025
Same author

In Vivo Imaging of Immune Rejection of MIN6 Cells Transplanted in C3H Mice.

Cells·2024
Same author

The Image-Histology Correlation of Subcutaneous mPEG-poly(Ala) Hydrogel-Embedded MIN6 Cell Grafts in Nude Mice.

Polymers·2023
Same author

Magnetic Resonance Imaging of Transplanted Porcine Neonatal Pancreatic Cell Clusters Labeled with Exendin-4-Conjugated Manganese Magnetism-Engineered Iron Oxide Nanoparticles.

Nanomaterials (Basel, Switzerland)·2022

Islet transplantation is a promising therapy for type 1 diabetes, restoring glucose control. Advances in methods and immunosuppression are improving success rates for this diabetes treatment.

Area of Science:

  • Endocrinology
  • Transplantation Immunology
  • Metabolic Diseases

Background:

  • Islet transplantation offers physiological glucose homeostasis restoration for diabetes.
  • Past human islet transplantation had limited success, but recent advancements show promise.
  • Type 1 diabetes management faces challenges, driving research into alternative therapies.

Purpose of the Study:

  • To review the progress and challenges in islet transplantation for type 1 diabetes.
  • To highlight methods improving islet graft survival and transplantation outcomes.
  • To discuss the potential of islet transplantation as a routine clinical treatment.

Main Methods:

  • Review of recent advancements in islet processing, preservation, and donor pool expansion.

Related Experiment Videos

  • Analysis of therapeutic strategies for improving islet engraftment and graft survival.
  • Examination of immunomodulation and immunoisolation techniques to overcome immune rejection.
  • Evaluation of newer immunosuppressants and tolerance-inducing agents.

    • Main Results:

    • Successful islet transplantations achieve near-normal glycemia and improve glucose metabolism.
    • Patients show normalized hepatic glucose production and enhanced tissue glucose disposal.
    • Complications are primarily related to the transplantation procedure and immunosuppressive drugs.

    Conclusions:

    • Islet transplantation is a viable therapeutic option for type 1 diabetes.
    • Further improvements in islet source availability and immunosuppression safety are needed for routine clinical use.
    • Continued research aims to make islet transplantation a standard treatment for diabetes.