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Is heart failure different on the two continents (North America and Europe)?

Rachel Hughes-Doichev1, Mark E Dunlap

  • 1Case Western Reserve University, Cleveland VA Medical Center, 10701 East Boulevard, Cleveland, OH 44106, USA.

Current Cardiology Reports
|April 13, 2004
PubMed

Insights

Heart failure is rising globally, with heart failure with preserved systolic function becoming more prevalent. Older adults need more clinical trials to ensure treatments are safe and effective for this growing population.

Area of Science:

  • Cardiology
  • Epidemiology
  • Geriatrics

Background:

  • Rising incidence of heart failure globally, particularly in North America and Europe.
  • Increasing recognition of heart failure with preserved systolic function (HFpEF).
  • HFpEF is linked to hypertension, aging, and female sex.

Purpose of the Study:

  • Compare heart failure similarities and differences between North America and Europe.
  • Analyze the characteristics and treatment of HFpEF.
  • Highlight the need for geriatric-focused clinical trials in heart failure.

Main Methods:

  • Comparative analysis of heart failure epidemiology and treatment guidelines across continents.
  • Review of patient demographics and comorbidities associated with HFpEF.
  • Assessment of current clinical trial populations.

Main Results:

  • Similarities and differences in heart failure prevalence and characteristics exist between North America and Europe.
  • HFpEF is a significant and growing concern on both continents.
  • Treatment guidelines show more similarities than differences, but treatment patterns vary.

Conclusions:

  • Heart failure management requires attention to continental differences and similarities.
  • The increasing prevalence of HFpEF necessitates tailored research.
  • Future heart failure clinical trials must adequately represent the aging population to ensure treatment efficacy and safety.

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