Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Physiology of cardiac resynchronization.

Usha Tedrow1, Michael O Sweeney, William G Stevenson

  • 1Tower 3-B, Cardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.

Current Cardiology Reports
|April 13, 2004
PubMed
Summary

Ventricular dyssynchrony worsens heart failure by impairing contraction and filling. Understanding these delays can improve patient selection and response to cardiac resynchronization therapy (CRT).

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ventricular tachycardia ablation using a lattice-tip ablation catheter and intracardiac echocardiography in the presence of a left ventricular assist device.

Heart rhythm·2026
Same author

Assessment of the Relevant Field of View of Unipolar Electrodes Using In Vivo Imaging.

JACC. Clinical electrophysiology·2026
Same author

Interobserver image registration variability impacts on stereotactic arrhythmia radioablation (STAR) target margins.

Biomedical physics & engineering express·2026
Same author

AI-Based QRS Onset Detection in the Early Ventricular Activation Site ECGs.

IEEE journal of biomedical and health informatics·2025
Same author

Atrial Fibrillation and Systemic Embolic Events in Patients With LMNA Cardiomyopathy.

Journal of the American College of Cardiology·2025
Same author

Hidden Patterns: Microvolt QRS Alternans, CV Heterogeneity, and the VT Circuit in Ischemic Cardiomyopathy.

JACC. Clinical electrophysiology·2025

Area of Science:

  • Cardiology
  • Electrophysiology
  • Heart Failure Research

Background:

  • Dyssynchronous ventricular contraction, linked to delayed electrical activation, exacerbates chronic dilated heart failure.
  • Impaired electromechanical synchrony presents in three distinct patterns, potentially amenable to pacing interventions.

Purpose of the Study:

  • To elucidate the mechanisms of cardiac dyssynchrony and its impact on heart failure.
  • To highlight the role of understanding dyssynchrony in optimizing cardiac resynchronization therapy (CRT).

Main Methods:

  • Review of existing literature on ventricular dyssynchrony and its clinical implications.
  • Analysis of the three levels of impaired electromechanical synchrony: prolonged atrioventricular (AV) delay, interventricular conduction delay, and intraventricular dyssynchrony.

Main Results:

  • Prolonged AV delay leads to presystolic mitral regurgitation and compromised left ventricular (LV) filling.
  • Interventricular delays (e.g., right ventricular (RV) preceding LV activation) impede LV filling and ejection.
  • Intraventricular dyssynchrony reduces contraction efficiency, increases mitral regurgitation, and promotes abnormal ventricular remodeling.

Conclusions:

  • Cardiac resynchronization therapy (CRT) benefits approximately two-thirds of patients selected by QRS duration.
  • A deeper comprehension of cardiac dyssynchrony pathophysiology is crucial for refining patient selection for CRT.
  • Improved understanding will enhance the assessment and optimization of CRT response in heart failure patients.

Related Experiment Videos