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[The relation between bone calcium metabolism and senile aortic valve calcification]
N Sugihara1, M Matsuzaki, Y Kato
1Second Department of Internal Medicine, University of Yamaguchi.
Insights
Bone mineral content impacts aortic valve calcification (AVC) and mitral annular calcification (MAC) in elderly individuals. Lower bone mineral content was significantly associated with calcification in females.
Area of Science:
- Gerontology
- Cardiovascular Medicine
- Bone Metabolism
Context:
- Aortic valve calcification (AVC) and mitral annular calcification (MAC) are common in the elderly.
- Bone metabolism plays a role in vascular calcification.
- Understanding the relationship between bone health and valvular calcification is crucial for geriatric cardiovascular care.
Purpose:
- To investigate the association between bone mineral content (BMC) and the prevalence and severity of aortic valve calcification (AVC) and mitral annular calcification (MAC) in elderly individuals.
- To explore potential differences in this association between sexes.
Summary:
- This study examined 189 elderly individuals (mean age 81.0 years) assessing bone mineral content (BMC) via quantitative computed tomography and valvular calcification (AVC and MAC) using echocardiography.
- Patients were categorized based on the presence and severity of calcification.
- In females, significantly lower BMC was observed in patients with MAC and AVC compared to those without calcification (p < 0.05). No significant differences in BMC were found among male groups.
Impact:
- Findings suggest a potential link between reduced bone mineral content and valvular calcification, particularly in elderly females.
- Highlights the importance of considering bone health in the context of cardiovascular disease in aging populations.
- May inform future research into therapeutic strategies targeting bone metabolism to prevent or manage valvular calcification.
Abstract:
The authors assessed the affect of bone calcium metabolism on aortic valve calcification (AVC) in 189 septua- and octogenarians (49 males and 140 females, 81.0 +/- 4.4 yrs). Both AVC and mitral annular calcification (MAC) were evaluated by two-dimensional echocardiography, and then the degree of AVC was classified into three categories; C-1: calcification seen in one cusp of the aortic valve, C-2: calcification in two cusps, and C-3: calcification in three cusps. Bone mineral content (BMC) of three lumbar vertebral bodies was obtained by quantitative computed tomography using a calibrated phantom. Serum calcium, phosphate, parathyroid hormone, calcitonin, and osteocalcin were also examined within a month. The patients were classified into age-matched five groups in both sexes; Group-C: MAC (-) and AVC (-) (n = 79); Group-A1: MAC (-) and AVC (+) with C-1 (n = 35); Group-A2: MAC (-) and AVC (+) with C-2 (n = 19); Group-A3: MAC (-) and AVC (+) with C-3 (n = 15); and Group-AM: MAC (+) and AVC (+) in any cusp (n = 42). In males, BMC decreased in the order of Groups-A3 (83 +/- 27 mg/cm3), -C (67 +/- 50), -AM (62 +/- 62), -A2 (61 +/- 38), and -A1 (59 +/- 58), but there was no significant difference between any of the five groups. In females, the BMC in Group-AM (29 +/- 24) was significantly less than that in Group-C (48 +/- 35) (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)