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Related Experiment Videos

Corneal thickness changes during herpes simplex virus disciform keratitis.

Kirk R Wilhelmus1, Joel Sugar, Robert A Hyndiuk

  • 1Cullen Eye Institute, Baylor College of Medicine, Houston, TX, USA. kirkw@bcm.tmc.edu

Cornea
|April 13, 2004
PubMed
Summary

Ultrasonic pachymetry revealed that corneal thickness in herpes simplex virus disciform corneal edema decreased by 15% during follow-up. This reduction, particularly significant in the initial two weeks, aids in assessing herpetic edema.

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Area of Science:

  • Ophthalmology
  • Virology
  • Corneal Diseases

Background:

  • Herpes simplex virus (HSV) keratitis can lead to disciform stromal edema, a significant cause of visual impairment.
  • Accurate monitoring of corneal thickness is crucial for managing this condition.

Purpose of the Study:

  • To quantify changes in corneal thickness using ultrasonic pachymetry during the follow-up of patients with herpes simplex virus disciform corneal edema.
  • To assess the correlation between corneal thickness and clinical signs of edema.

Main Methods:

  • A cohort of 35 patients diagnosed with herpetic keratitis was studied.
  • Ultrasonic pachymetry and slit-lamp biomicroscopy were employed for measurements.
  • Corneal thickness was tracked during follow-up and at the point of clinical resolution.

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Main Results:

  • Corneal thickness in disciform stromal keratitis showed a 15% decrease during the follow-up period (95% CI: 10% to 20%).
  • A substantial portion (65%) of this decrease occurred within the first two weeks of follow-up (95% CI: 43% to 88%).
  • Elevated central corneal thickness, as measured by pachymetry, was significantly associated with the clinical detection of corneal edema (P = 0.03).

Conclusions:

  • Ultrasonic pachymetry provides valuable quantitative data that complements clinical examinations in diagnosing and monitoring herpetic disciform edema.
  • Corneal thickness measurements can objectively support the clinical assessment of edema resolution.