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Related Experiment Videos

Urethral dysfunction in diabetic rats.

Kazumasa Torimoto1, Matthew O Fraser, Yoshihiko Hirao

  • 1Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213-3221, USA.

The Journal of Urology
|April 13, 2004
PubMed
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Diabetes mellitus impairs urethral relaxation during bladder contractions in rats, affecting both smooth and striated muscles. L-arginine therapy shows promise in restoring this function by boosting nitric oxide production.

Area of Science:

  • Urology
  • Endocrinology
  • Physiology

Background:

  • Diabetes mellitus (DM) is a complex metabolic disorder with widespread systemic effects.
  • Urethral function is crucial for lower urinary tract symptoms and continence.
  • The impact of DM on urethral relaxation mechanisms during bladder voiding is not fully understood.

Purpose of the Study:

  • To investigate the effects of diabetes mellitus on urethral relaxation mechanisms during reflex bladder contractions in a rat model.
  • To elucidate the roles of smooth and striated muscle components in diabetic urethral dysfunction.

Main Methods:

  • Diabetes was induced in rats via streptozotocin injection.
  • Urethral relaxation was assessed by simultaneous recordings of intravesical pressure and urethral perfusion pressure (UPP) under isovolumetric conditions.

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  • The effects of L-arginine (nitric oxide synthase substrate) and Nomega-nitro-L-arginine (NO synthase inhibitor) were evaluated.

    • Main Results:

    • Diabetic rats exhibited significantly higher UPP nadir and intravesical pressure thresholds for urethral relaxation compared to normal rats.
    • The rate and amplitude of high-frequency oscillations in urethral striated muscle were significantly lower in diabetic rats.
    • L-arginine administration improved urethral relaxation in diabetic rats, an effect inhibited by NO synthase inhibition.

    Conclusions:

    • Diabetes mellitus induces smooth and striated muscle dysfunctions in the urethral outlet during reflex bladder contractions.
    • L-arginine therapy, by enhancing nitric oxide production, may partially restore urethral relaxation mechanisms in diabetic individuals.