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Related Experiment Videos

Irreversible intestinal failure.

Olivier Goulet1, Frank Ruemmele, Florence Lacaille

  • 1Département de Gastroentérologie, Hépatologie et Nutrition Pédiatriques, Hôpital Necker- Infants Malades and INSERM, Faculté de Necker, Paris, France. olivier.goulet@nck.ap-hop-paris.fr

Journal of Pediatric Gastroenterology and Nutrition
|April 13, 2004
PubMed
Summary

Intestinal failure (IF) is a severe reduction in gut function, often requiring long-term parenteral nutrition (PN). This review explores causes of irreversible IF and strategies for its management.

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Area of Science:

  • Gastroenterology
  • Pediatric Gastroenterology
  • Surgical Gastroenterology

Background:

  • Intestinal failure (IF) significantly impairs nutrient and fluid absorption, necessitating parenteral nutrition (PN).
  • Common causes include short bowel syndrome, congenital enterocyte disorders, and severe motility issues.
  • Long-term PN can lead to complications like sepsis and liver disease, impacting patient outcomes.

Purpose of the Study:

  • To review the causes of irreversible intestinal failure.
  • To emphasize medico-surgical strategies for prevention and treatment across different stages of IF.
  • To discuss current and emerging therapeutic options.

Main Methods:

  • Comprehensive literature review of intestinal failure.
  • Analysis of etiological factors and treatment modalities.

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  • Evaluation of surgical and medical interventions.

    • Main Results:

    • Short bowel syndrome is a primary cause, with most patients recovering function. However, some develop permanent intestinal insufficiency.
    • Congenital enterocyte diseases and motility disorders often result in irreversible IF.
    • Parenteral nutrition is the mainstay, but complications necessitate careful management and consideration for intestinal transplantation.

    Conclusions:

    • Irreversible intestinal failure presents significant challenges, requiring tailored management strategies.
    • While PN is crucial, advancements in surgical and hormonal therapies offer potential for improved outcomes.
    • Intestinal transplantation remains an option for select patients with severe complications.