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Published on: May 7, 2013
Lipopolysaccharide evoked peptide release by calcium-induced calcium release
Xiaomei Qin1, Lingfei Hou, Xian Wang
1Institute of Vascular Medicine, Peking University Third Hospital, Beijing 100083, PR China.
Abstract:
Calcium may play a key role in the lipopolysaccharide (LPS)-induced release of calcitonin gene-related peptide in rat dorsal root ganglion neurons. Both calcium entry via voltage-activated calcium channels sensitive to either omega-conotoxin GVIA or omega-agatoxin IVA, and calcium release from ryanodine-sensitive calcium stores were involved in this process. Cyclic ADP-ribose antagonist affected neither the enhancement of cytoplasmic free calcium nor the release of calcitonin gene-related peptide induced by LPS. These findings underscore a pivotal role of calcium-induced calcium release in lipopolysaccharide-stimulated calcitonin gene-related peptide release from nociceptive neurons.
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