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Related Experiment Videos

Lysosomes in cell death.

Maria Eugenia Guicciardi1, Marcel Leist, Gregory J Gores

  • 1Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

Oncogene
|April 13, 2004
PubMed
Summary
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Lysosomal cathepsins, not just caspases, are key players in programmed cell death. This review explores the lysosomal pathway of apoptosis and its role in health and disease.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Apoptosis research traditionally centered on caspases as primary executioners of programmed cell death.
  • Emerging evidence highlights the significant involvement of lysosomal cathepsins in apoptosis.
  • The concept of a 'lysosomal pathway of apoptosis' is now widely recognized.

Purpose of the Study:

  • To review the molecular mechanisms and key players in the lysosomal pathway of apoptosis.
  • To discuss the activation triggers of this pathway, including death receptors and photodamage.
  • To emphasize the relevance of lysosomal apoptosis in both physiological development and pathological conditions.

Main Methods:

  • Literature review and synthesis of existing research on apoptosis.

Related Experiment Videos

  • Analysis of molecular mechanisms involving lysosomal proteases and their cytosolic release.
  • Examination of experimental models demonstrating the lysosomal pathway's function.

    • Main Results:

    • Lysosomal proteases, such as cathepsins, contribute to the apoptotic cascade.
    • This lysosomal pathway can be initiated by various stimuli, including death receptors and environmental damage.
    • Lysosomal enzyme release into the cytosol precedes mitochondrial involvement in some apoptotic events.

    Conclusions:

    • Lysosomes and their enzymes play a crucial role in initiating and executing apoptosis, particularly in disease.
    • The lysosomal pathway offers a complementary mechanism to caspase-dependent apoptosis.
    • Understanding this pathway is vital for comprehending cellular death in development and pathology.