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Related Experiment Videos

Somatostatin receptor subtypes: basic pharmacology and tissue distribution.

V D Corleto1, S Nasoni, F Panzuto

  • 1Department of Digestive and Liver Diseases, II School of Medicine and Surgery, University of La Sapienza, S. Andrea Hospital, Via di Grottarossa 1035, 00189 Rome, Italy. corleto@bce.uniroma1.it

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
|April 14, 2004
PubMed
Summary

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Somatostatin receptors, a key G-protein-coupled receptor group, are involved in diverse physiological processes. Research explores their binding, regulation, and expression across species.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Pharmacology

Background:

  • Heptahelical receptors are a large superfamily of transmembrane-signalling molecules.
  • Somatostatin receptors (SSTRs) are a distinct subgroup within this superfamily, crucial for various physiological functions.
  • SSTR subtypes share significant sequence and mRNA homology across species.

Purpose of the Study:

  • To review the characteristics of somatostatin receptors.
  • To discuss proposed models of ligand-binding interactions.
  • To outline receptor regulation mechanisms and expression patterns.

Main Methods:

  • Analysis of existing literature on somatostatin receptor structure and function.
  • Review of studies on receptor binding, functional activity, and cellular expression.

Related Experiment Videos

  • Comparison of receptor subtypes across different species.

    • Main Results:

    • Somatostatin receptors exhibit conserved residues and high mRNA homology.
    • Two models for ligand-binding interaction are proposed: a binding pocket model and an interaction domain model.
    • Receptor regulation involves desensitisation, internalisation, and degradation; subtypes are expressed in various human and rodent tissues.

    Conclusions:

    • Somatostatin receptors are complex transmembrane-signalling molecules with conserved structural and functional properties.
    • Understanding ligand-binding and regulatory mechanisms is essential for elucidating SSTR roles.
    • Differential expression patterns suggest diverse physiological roles for somatostatin receptor subtypes.