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Rorgamma (Rorc) is a common integration site in type B leukemogenic virus-induced T-cell lymphomas
Dana R Broussard1, Mary M Lozano, Jaquelin P Dudley
1Section of Microbiology and Molecular Genetics and Institute of Cellular and Molecular Biology, Austin, Texas 78712, USA.
Journal of Virology
|April 14, 2004
Abstract:
The retrovirus type B leukemogenic virus (TBLV) causes T-cell lymphomas in mice. We have identified the Rorgamma locus as an integration site in 19% of TBLV-induced tumors. Overexpression of one or more Rorgamma isoforms in >77% of the tumors tested may complement apoptotic effects of c-myc overexpression.