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Updated: Aug 24, 2026

Escherichia coli -Based Complementation Assay to Study the Chaperone Function of Heat Shock Protein 70
Published on: March 8, 2024
[Relationship between heat shock protein 70-hom gene polymorphism and ankylosing spondylitis]
Jing-an Lin1, De-fu Ye, Yue-yong Zhu
1Center of Research, First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350005 PR China. Linjingan@21cn.com
Objective:
To investigate the association between heat shock protein 70-hom (HSP70-hom) gene polymorphism and ankylosing spondylitis(AS) in Chinese Han patients.
Methods:
Genomic DNA from 98 Chinese AS patients and 70 ethnically matched controls were typed for HSP70-hom polymorphism by polymerase chain reaction-restriction fragment length polymorphism.
Results:
The HSP70-hom genotypes in the AS patients consisted of homozygote AA (60.2%) and BB(4.1%), and heterozygote(35.7%), while the HSP70-hom genotypes in the controls were composed of AA(58.6%), BB(2.9%) and heterozygote(38.6%). No significant difference was found in the distribution of HSP70-hom genotype between these two groups(chi(2) test=0.280, P>0.05). The frequencies of HSP70-hom alleles in AS patients were 77.9%(AA) and 22.1%(BB), while they were 78.1% and 21.9% in the controls. The frequency of HSP70-hom allele in AS patients was not significantly increased, compared with that in controls (chi(2) test=0.002, P>0.05).
Conclusion:
There may be no association between the HSP70-hom gene polymorphism and ankylosing spondylitis in Chinese Han population.
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