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Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

Antibacterial resistance

Jocelyn Y Ang1, Elias Ezike, Basim I Asmar

  • 1Division of Infectious Diseases, Children's Hospital of Michigan, Detroit Medical Center, Department of Pediatrics, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA.

Indian Journal of Pediatrics
|April 15, 2004
PubMed

Insights

Antimicrobial resistance is a growing threat, increasing illness, death, and healthcare costs. This review covers drug-resistant bacteria like MRSA and VRE in children, focusing on prevention and treatment strategies.

Area of Science:

  • Pediatric Infectious Diseases
  • Antimicrobial Resistance
  • Public Health

Background:

  • Antimicrobial resistance (AMR) poses a significant global health challenge, leading to increased morbidity, mortality, and healthcare expenditures.
  • Key contributing factors to AMR include antibiotic overuse, inadequate infection control, prolonged hospitalization, intensive care unit admissions, and invasive procedures.

Purpose of the Study:

  • To review the epidemiology, mechanisms of resistance, treatment, and prevention of infections caused by multidrug-resistant organisms in pediatric patients.
  • To discuss antibacterial resistance in Gram-negative organisms, including extended-spectrum beta-lactamase (ESBL) producing bacteria, and their management.

Main Methods:

  • Literature review focusing on pediatric infections caused by specific multidrug-resistant pathogens.
  • Synthesis of information on epidemiology, resistance mechanisms, clinical manifestations, treatment options, and prevention strategies.

Main Results:

  • Detailed review of common pediatric resistant pathogens: Streptococcus pneumoniae, Staphylococcus aureus (MRSA), Streptococcus pyogenes, and Enterococci (VRE).
  • Discussion of resistance trends and challenges posed by Gram-negative bacteria, such as ESBL-producing Enterobacteriaceae.

Conclusions:

  • Effective infection control measures and judicious antibiotic use are crucial for combating pediatric antimicrobial resistance.
  • Comprehensive strategies encompassing surveillance, treatment, and prevention are essential to mitigate the impact of multidrug-resistant infections in children.

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