Related Experiment Video
Updated: Aug 12, 2026
![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)
Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Synthesis and evaluation of some new spiro indoline-based heterocycles as potentially active antimicrobial agents
A H Abdel-Rahman1, E M Keshk, M A Hanna
1Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt. mahanna69@hotmail.com
Abstract:
Several new spiro indoline-based heterocycles were synthesized by prior preparation of the 4-(2'-oxo-indol-3'-ylidene)-oxazol-5-one derivatives and subsequent reaction of the produced indol-3-ylidene based heterocycles with activated nitrile reagents. The obtained products were allowed to react with hydrazine hydrate in alcoholic basic to give the target compounds. Structure of these products was confirmed on the bases of elemental as well as spectral data. Representative compounds of the hitherto synthesized products were tested and evaluated as antimicrobial agents.
More Related Videos
Related Concept Videos
Cycloaddition Reactions: Overview
Diels–Alder Reaction Forming Cyclic Products: Stereochemistry
Five-Membered Heterocyclic Aromatic Compounds: Overview
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry

