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Synthesis and biochemical properties of E-ring modified luotonin A derivatives
Ali Cagir1, Shannon H Jones, Brian M Eisenhauer
1Departments of Chemistry and Biology, University of Virginia, Charlottesville, VA 22901, USA.
Bioorganic & Medicinal Chemistry Letters
|April 15, 2004
Abstract:
Luotonin A is a cytotoxic pyrroloquinazolinoquinoline alkaloid that has been shown to stabilize the human topoisomerase I-DNA covalent binary complex in the same fashion as the antitumor alkaloid camptothecin. A study of the structural elements in luotonin A required for binary complex stabilization has revealed key differences relative to those required for camptothecin.