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Pharmaceutical suspensions: micro electrophoretic properties
The Journal of Pharmacy and Pharmacology
|March 1, 1977
Summary
This study investigated the zeta potential and particle charge of four drugs in aqueous dispersion. Surfactants significantly altered these properties, offering insights into drug formulation and stability.
Area of Science:
- Physical Chemistry
- Pharmaceutical Sciences
- Materials Science
Background:
- Understanding drug particle charge is crucial for formulation stability and delivery.
- Microelectrophoretic properties influence drug dispersion behavior in aqueous media.
Purpose of the Study:
- To examine the microelectrophoretic properties and zeta potentials of griseofulvin, betamethasone, nalidixic acid, and thiabendazole in aqueous dispersion.
- To investigate the impact of pH on drug particle charge.
- To assess the effect of various surfactants on the electrophoretic properties of these drug dispersions.
Main Methods:
- Microelectrophoresis was used to measure particle mobilities.
- Zeta potentials were calculated from measured mobilities.
- The influence of anionic, cationic, and non-ionic surfactants on electrophoretic properties was evaluated.
Main Results:
- Particle charge varied with the pH of the dispersion, correlating with drug chemical structure and surface characteristics.
- Anionic, cationic, and non-ionic surfactants, as well as their mixtures, significantly modified the electrophoretic properties of the drug dispersions.
- Observed surfactant effects were consistent with those found in model polystyrene latex systems.
Conclusions:
- The study provides valuable data on the electrokinetic behavior of specific drug particles in aqueous systems.
- Surface-active agents can effectively modulate the surface charge and electrophoretic mobility of drug particles.
- Findings contribute to the understanding of drug dispersion stability and potential for controlled delivery.