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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Design, synthesis and cytotoxicity of 7-deoxy aryl discodermolide analogues
Mark A Burlingame1, Simon J Shaw, Kurt F Sundermann
1Department of Chemistry, Kosan Biosciences Inc, 3832 Bay Center Place, Hayward, CA 94545, USA. burlingame@kosan.com
Bioorganic & Medicinal Chemistry Letters
|April 15, 2004
Abstract:
A series of 7-deoxy discodermolide analogues in which the lactone fragment 'C' was replaced by aryl substituents were designed, synthesized, and evaluated for cytotoxicity.
