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Linezolid-induced bradycardia: a case report
Alfredo Tartarone1, Giuseppina Gallucci, Giovanni Iodice
1Division of Medical Oncology and Haematology, Centro di Riferimento Oncologico della Basilicata, Strada Provinciale No. 8, 85028 Rionero in Vulture (PZ), Italy. tarta1@virgilio.it
International Journal of Antimicrobial Agents
|April 15, 2004
Summary
Severe bradycardia occurred in a patient during linezolid antibiotic treatment, suggesting a causal link. This adverse event highlights the need for caution when administering linezolid to patients with jaundice and liver issues.
Area of Science:
- Pharmacology
- Infectious Diseases
- Clinical Medicine
Background:
- Linezolid is a novel oxazolidinone antibiotic effective against Gram-positive bacteria.
- Jaundice and hepatic insufficiency are common complications in certain patient populations.
Observation:
- A 49-year-old woman with fever and malignant jaundice developed severe bradycardia.
- The bradycardia emerged during antibiotic therapy with linezolid.
Findings:
- A strong temporal association was observed between linezolid administration and the onset of severe bradycardia.
- This case represents the first reported instance of linezolid-induced bradycardia.
Implications:
- Linezolid should be used with caution in patients presenting with jaundice and hepatic insufficiency.
- This finding underscores the importance of monitoring cardiac function during linezolid treatment in at-risk individuals.