Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Melt pelletization with polyethylene glycol in a rotary processor.

Thomas Vilhelmsen1, Jakob Kristensen, Torben Schaefer

  • 1Department of Pharmaceutics, The Danish University of Pharmaceutical Sciences, 2 Universitetsparken, DK-2100 Copenhagen, Denmark.

International Journal of Pharmaceutics
|April 15, 2004
PubMed
Summary

This study explored melt pelletization using a rotary processor, finding that increased binder concentration, massing time, and rotation speed enhance agglomerate size. The rotary processor is a viable alternative for melt pelletization.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Haematology and clinical blood chemistry in harbour porpoises (Phocoena phocoena) from the inner Danish waters.

Environment international·2020
Same author

Quantification of Fragmentation of Pharmaceutical Materials After Tableting.

Journal of pharmaceutical sciences·2018
Same author

Wet granulation in rotary processor and fluid bed: Comparison of granule and tablet properties.

AAPS PharmSciTech·2017
Same author

Effect of food intake and co-administration of placebo self-nanoemulsifying drug delivery systems on the absorption of cinnarizine in healthy human volunteers.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2016
Same author

Kolliphor surfactants affect solubilization and bioavailability of fenofibrate. Studies of in vitro digestion and absorption in rats.

Molecular pharmaceutics·2015
Same author

Pharmaceutical microparticle engineering with electrospraying: the role of mixed solvent systems in particle formation and characteristics.

Journal of materials science. Materials in medicine·2015

Area of Science:

  • Pharmaceutical Technology
  • Chemical Engineering
  • Materials Science

Background:

  • Melt pelletization is crucial for pharmaceutical formulation.
  • Rotary processors offer potential for efficient melt agglomeration.

Purpose of the Study:

  • To investigate the impact of process parameters on melt pelletization in a rotary processor.
  • To evaluate lactose monohydrate melt agglomeration with polyethylene glycol (PEG) 3000.

Main Methods:

  • Full factorial design was employed.
  • Key parameters studied: airflow, binder concentration, massing time, friction plate rotation speed, and surface structure.
  • Lactose monohydrate and PEG 3000 were used as model materials.

Main Results:

Related Experiment Videos

  • Increased binder concentration, massing time, and rotation speed led to larger agglomerates.
  • Enhanced shearing forces (via friction plate surface structure) also increased agglomerate size.
  • Narrower size distribution was achieved with higher binder concentration and shearing forces.
  • Increased shearing forces resulted in greater material adhesion to the friction plate.

Conclusions:

  • The rotary processor is a suitable alternative to high shear mixers for melt pelletization.
  • Process parameters significantly influence agglomerate size and distribution.
  • Understanding these parameters is key for optimizing melt agglomeration processes.