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Updated: Aug 24, 2026

In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Trigeminal Ganglia
Published on: August 1, 2025
NMDA receptor-dependent long-term potentiation is dependent on low-voltage-activated calcium currents in the
Hirofumi Kitagawa1, Ken Inoue, Atsushi Nishida
1Department of Neural Science, Faculty of Medicine, Mie University, Tsu 514-0008, Japan. hkitagaw@clin.medic.mie-u.ac.jp
Abstract:
The role of low-voltage-activated (LVA) calcium channels in the expression of long-term potentiation (LTP) was examined by intracellular recording in slices from cat agranular cortex. In the normal solution, LTP was induced, and the potentiation of low-threshold rebound potential was evoked by negative current injection. In the cells, in which resting membrane potential was depolarized, the incidence of LTP was very low. LTP was blocked completely in the presence of NMDA receptor antagonist or 50-100 microM nickel. It was suggested that LVA calcium channels function downstream of NMDA receptor-dependent signaling.
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