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IgG- and IgE-mediated antigen presentation on MHC class II

Andrew Getahun1, Birgitta Heyman

  • 1Department of Genetics and Pathology, Uppsala University, Uppsala SE-751 85, Sweden. andrew.getahun@genpat.uu.se

Immunology Letters
|April 15, 2004
PubMed

IgG- and IgE-antibodies have the ability to enhance the production of antibodies directed against the antigen they are specific for. It has been suggested that the mechanism behind IgG- and IgE-mediated feedback enhancement is the ability of these isotypes to induce a more potent antigen-specific T helper cell response, increasing the chances that antigen-specific B cells receive the T cell help they require to become antibody-producing cells. With emphasis on the murine system, we will here focus on the ability of IgG and IgE to capture antigen and facilitate presentation of antigenic peptides to T helper cells. Whether this mechanism underlies feedback enhancement of antibody responses to these antigens will be discussed.

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