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Updated: Aug 24, 2026

Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
Published on: February 4, 2017
Synthesis, biodistribution and quantitative structure-activity relationship studies of new 99mTc labeled
Huabei Zhang1, Mei Dai, Chuanmin Qi
1Department of Chemistry, Beijing Normal University, Beijing 100875, China.
Abstract:
Twelve new peptide or pseudo-peptide chelators have been synthesized in the course of our continuing investigation of 99mTc-labelled peptides for application for renal imaging agents. All compounds were characterized on the basis of, IR, 1HNMR, 13CNMR spectroscopy, as well as MS and elemental analysis. All peptides yield stable 99mTc complexes using Sn(II) reactive coupling and exhibit renal uptake. Linear regression analysis between Logarithm of renal uptake value (RU) and the parameters obtained by the ZINDO/1 method was performed. Some equations were obtained which showed that molecular polar and charge have some relationship with their renal uptake.
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