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Related Experiment Videos

Do valved stents compromise coronary flow?

Christoph H Huber1, Piergiorgio Tozzi, Antonio F Corno

  • 1Service de Chirurgie Cardiovasculaire, Centre Hospitalier Universitaire Vaudois CHUV, 1011 Lausanne, Switzerland. huberch@dr.com

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery
|April 15, 2004
PubMed
Summary
This summary is machine-generated.

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This study evaluated a new self-expanding valved stent for aortic valve replacement. The device showed excellent acute valve function without interfering with coronary blood flow in animal models.

Area of Science:

  • Cardiovascular Surgery
  • Biomedical Engineering
  • Interventional Cardiology

Background:

  • Minimal invasive aortic valve implantation is crucial for patients with aortic valve disease.
  • New stent designs are needed to improve safety and efficacy.
  • Coronary artery obstruction remains a concern with some valve implantation techniques.

Purpose of the Study:

  • To evaluate a novel self-expanding valved stent for minimally invasive aortic valve implantation.
  • To assess the stent's interference with coronary blood flow.
  • To determine the acute performance and safety of the new stent design.

Main Methods:

  • An equine pericardial valve on a self-expanding nitinol stent was tested in vitro and in vivo in six calves.
  • Valve stents were implanted in the orthotopic aorta, on- or off-pump.

Related Experiment Videos

  • In vivo assessment included intracardiac ultrasound, coronary blood flow analysis, and hemodynamic measurements.

    • Main Results:

    • The valved stent demonstrated good leaflet motion and a mean valve orifice of 1.75 cm².
    • No coronary flow impairment was observed, with a residual-coronary sinus stent index (RCSSI) of 1.8.
    • Low transvalvular gradients were recorded, with mild regurgitation or paravalvular leak in two devices due to size mismatch.

    Conclusions:

    • The new self-expanding valved stent design facilitates on- and off-pump aortic valve implantation.
    • The device functions well in the orthotopic aorta without compromising coronary blood flow.
    • Proper sizing is essential for optimal acute valve function and minimal complications.