Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Non-steroidal anti-inflammatory drugs decrease the quality of pleurodesis after mechanical pleural abrasion.

D Lardinois1, P Vogt, L Yang

  • 1Division of Thoracic Surgery, University Hospital, Zurich, Switzerland. didier.lardinois@usz.ch

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery
|April 15, 2004
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adoptive cell therapy with tumor-infiltrating lymphocytes in combination with nivolumab in patients with advanced melanoma.

Immuno-oncology technology·2025
Same author

Integrated functional and spatial profiling of tumour immune responses induced by immunotherapy: the <i>iPROFILER</i> platform.

Immuno-oncology technology·2022
Same author

Postoperative deep wound dehiscence of thoracotomy with isolation of Corynebacterium tuberculostearicum: surgical site infection or colonization?

European review for medical and pharmacological sciences·2017
Same author

Abstracts from the 8th Annual Meeting of the Scientific Association of Swiss Radiation Oncology (SASRO).

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2016
Same author

Diagnostic value of immunohistochemistry on formalin-fixed, paraffin-embedded skin biopsy specimens for bullous pemphigoid.

The British journal of dermatology·2016
Same author

Regorafenib-induced hand-foot skin reaction with striking epidermal dysmaturation - a new histopathological pattern associated with the use of multi-kinase inhibitors.

The British journal of dermatology·2016

Non-steroidal anti-inflammatory drugs (NSAIDs) reduce the density of pleural adhesions after mechanical abrasion. Avoid NSAIDs for pain management during pleurodesis to improve adhesion quality.

Area of Science:

  • Thoracic Surgery
  • Pain Management
  • Wound Healing

Background:

  • Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for post-thoracic surgery pain.
  • NSAIDs inhibit prostaglandin synthesis, potentially affecting collagen deposition and adhesion formation.
  • Endoscopic mechanical pleural abrasion is a therapeutic procedure for pneumothorax, often leading to pleural adhesions.

Purpose of the Study:

  • To investigate the impact of NSAIDs on adhesion formation following mechanical pleural abrasion.
  • To evaluate the effect of diclofenac on the quality and density of pleural adhesions in a porcine model.

Main Methods:

  • A porcine model underwent unilateral video-assisted thoracoscopic surgery with mechanical pleural abrasion.
  • Animals were divided into a treatment group receiving daily diclofenac and a control group.

Related Experiment Videos

  • Pleurodesis efficacy was assessed macroscopically and microscopically, evaluating adhesion severity, distribution, and collagen deposition.

    • Main Results:

    • The NSAID treatment group exhibited significantly less dense adhesions compared to the control group (pleurodesis score 2 vs. 3.67, P=0.01).
    • Histopathology revealed less collagen deposition in the NSAID group, indicating looser granulation tissue formation.
    • Adhesion distribution and inflammatory reaction were comparable between the groups.

    Conclusions:

    • Perioperative NSAID use significantly alters the quality of pleural adhesions after mechanical abrasion in a porcine model.
    • These findings suggest that NSAIDs may negatively impact the desired outcome of pleurodesis.
    • NSAIDs should be used cautiously or avoided for pain management when pleurodesis is intended.