Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The prefrontal cortex and working memory: physiology and brain imaging.

Dick Passingham1, Katsuyuki Sakai

  • 1Department of Experimental Psychology, University of Oxford, United Kingdom. dick.passingham@psy.ox.ac.uk

Current Opinion in Neurobiology
|April 15, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biosynthesis of reveromycin derivatives by altering the regioselectivity of cytochrome P450revI.

Chemical science·2025
Same author

Synthesis and biological evaluation of burnettiene A derivatives enabling discovery of novel fungicide candidates.

Journal of pesticide science·2024
Same author

Iron-sulphur protein catalysed [4+2] cycloadditions in natural product biosynthesis.

Nature communications·2024
Same author

Discovery of an antimalarial compound, burnettiene A, with a multidrug-sensitive Saccharomyces cerevisiae screening system based on mitochondrial function inhibitory activity.

Bioscience, biotechnology, and biochemistry·2024
Same author

Production of Kinanthraquinone D with Antimalarial Activity by Heterologous Gene Expression and Biotransformation in <i>Streptomyces lividans</i> TK23.

Journal of natural products·2024
Same author

Total Synthesis of Fusaramin, Enabling Stereochemical Elucidation, Structure-Activity Relationship, and Uncovering the Hidden Antimicrobial Activity against Plant Pathogenic Fungi.

Organic letters·2024

Sustained neural activity in the prefrontal cortex during working memory tasks supports prospective behavior, not just information maintenance. This activity involves multiple cognitive factors across species.

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience

Background:

  • Sustained neural activity is observed in the prefrontal cortex during working memory tasks.
  • Understanding the precise role of this activity is crucial for cognitive function.

Purpose of the Study:

  • To compare the anatomical distribution of sustained prefrontal cortex activity in humans and monkeys.
  • To elucidate the functional significance of this sustained activity in working memory.

Main Methods:

  • Comparative neuroanatomical analysis of prefrontal cortex activity.
  • Electrophysiological recordings during working memory tasks in humans and monkeys.

Main Results:

  • Sustained activity in the prefrontal cortex reflects item maintenance, response preparation, item transformation, task rules, and goals.

Related Experiment Videos

  • Similar patterns of sustained activity are observed in both humans and monkeys.
  • Sustained activity is also present in other brain regions, including the parietal cortex.

    • Conclusions:

    • Prefrontal cortex sustained activity is not solely for sensory information maintenance.
    • This activity is critical for the prospective use of information to guide behavior.
    • Working memory involves a distributed network, with the prefrontal cortex playing a key role in behavioral planning.