Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Encoding meal in integrated vagal afferent discharge.

G Królczyk1, D Zurowski, J Sobocki

  • 1Department of Pathophysiology, Jagiellonian University, Cracow, Poland. mbkrolcz@cyf-kr.edu.pl

Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
|April 15, 2004
PubMed
Summary

Vagal afferent nerves signal fullness to the brain. This study shows distinct nerve firing patterns (high amplitude, low frequency) in fasted rats, indicating how the gastrointestinal tract communicates interdigestive information.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of particle size and weight fraction of SiC on the mechanical, tribological, morphological, and structural properties of Al-5.6Zn-2.2Mg-1.3Cu composites using RSM: fabrication, characterization, and modelling.

Heliyon·2022
Same author

Evaluation of selected protein biomarkers of renal function in rats with an experimental model of acute cyclophosphamide-induced cystitis treated with N-acetylcysteine.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2020
Same author

Prostaglandin-targeting agents and spectral heart rate variability in experimental partial bladder outlet obstruction in rats.

Physiology international·2016
Same author

Exogenous melatonin abolishes mechanical allodynia but not thermal hyperalgesia in neuropathic pain. The role of the opioid system and benzodiazepine-gabaergic mechanism.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2013
Same author

Pulsed electromagnetic field affects intrinsic and endoplasmatic reticulum apoptosis induction pathways in MonoMac6 cell line culture.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2012
Same author

Pulsating electromagnetic field stimulation of urothelial cells induces apoptosis and diminishes necrosis: new insight to magnetic therapy in urology.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2012

Area of Science:

  • Neuroscience
  • Gastroenterology
  • Physiology

Background:

  • The vagus nerve plays a crucial role in regulating gastrointestinal functions through afferent signaling.
  • Understanding vagal afferent activity is key to deciphering the feedback mechanisms controlling food intake and satiety.

Purpose of the Study:

  • To investigate and characterize vagal afferent discharge patterns in response to feeding and gastric distension in a rat model.
  • To determine how different physiological states (fasted vs. fed) and mechanical stimuli influence vagal nerve activity.

Main Methods:

  • Electrophysiological recordings of vagal afferents were performed in rats under fasted, fed, and gastric distension conditions.
  • Vagal discharge patterns were analyzed using a dual time-amplitude window discriminator.

Related Experiment Videos

  • Gastric distension was induced using a balloon catheter inserted via the esophagus.

    • Main Results:

    • Total vagal afferent discharge was significantly higher in fed rats compared to fasted rats (0.56 +/- 0.22 Hz vs. 0.3 +/- 0.12 Hz).
    • Two distinct discharge patterns were identified: high amplitude low frequency (HALF) and low amplitude high frequency (LAHF).
    • HALF spikes were more prevalent in fasted rats, while LAHF spikes predominated in fed rats. Vagal discharge increased proportionally with gastric distension volume in both left and right vagal afferents.

    Conclusions:

    • Vagal afferent activity differs significantly between fasted and fed states, reflecting the gastrointestinal tract's response to food.
    • The high amplitude low frequency (HALF) spike pattern in vagal afferents appears to encode interdigestive information from the gastrointestinal tract.
    • Gastric distension elicits a dose-dependent increase in vagal afferent discharge, highlighting its role in mechanosensory signaling.