Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

EEG sedation for children with autism.

Uday C Mehta1, Indubhai Patel, Frank V Castello

  • 1Neurodevelopmental Pediatrics, Children's Specialized Hospital, Mountainside, New Jersey 07092, USA. umehta@childrens-specialized.org

Journal of Developmental and Behavioral Pediatrics : JDBP
|April 15, 2004
PubMed
Summary

Clonidine effectively sedates children with autism and pervasive developmental disorder (PDD) for electroencephalograms (EEGs). This study found clonidine to be a safe and viable alternative for pediatric sedation when other agents fail.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Predictors of Clinically Significant Anxiety in Non-autistic Siblings of Children With Autism.

Journal of developmental and behavioral pediatrics : JDBP·2026
Same journal

Game-based Cognitive Training for School-age Children Living With or Exposed to HIV: A Randomized Controlled Trial in Uganda and Malawi.

Journal of developmental and behavioral pediatrics : JDBP·2026
Same journal

Challenging Case-In the Teens it Takes a Team.

Journal of developmental and behavioral pediatrics : JDBP·2026
Same journal

Intensive Outpatient Treatment for Patients With Severe Externalizing Behavior and Intellectual and Developmental Disability: An Electronic Health Record Review.

Journal of developmental and behavioral pediatrics : JDBP·2026
Same journal

Positive Parenting is Associated With Higher Self-reported Resilience in Children With Attention-Deficit Hyperactivity Disorder.

Journal of developmental and behavioral pediatrics : JDBP·2026
Same journal

Weight and Health Behavior Conversations in Adolescent Primary Care: A Qualitative Examination.

Journal of developmental and behavioral pediatrics : JDBP·2026

Area of Science:

  • Pediatric Neurology
  • Developmental Neuroscience
  • Clinical Pharmacology

Background:

  • Children with autism and pervasive developmental disorder (PDD) have a higher incidence of seizures.
  • Diagnostic electroencephalograms (EEGs) are crucial for evaluating seizures in these children.
  • Existing pediatric sedatives, such as chloral hydrate, are often ineffective for this population.

Purpose of the Study:

  • To evaluate the efficacy and safety of clonidine as a conscious sedation agent for EEG recordings in children with autism and PDD.
  • To compare clonidine's effectiveness against previous sedation attempts with other agents.
  • To assess the impact of clonidine on vital signs and EEG technical quality.

Main Methods:

  • A prospective study involving 27 children diagnosed with autism and PDD undergoing EEG.

Related Experiment Videos

  • Oral administration of clonidine (0.05-0.2 mg) for conscious sedation.
  • Continuous monitoring of pulse rate, respiration rate, blood pressure, and oxygen saturation by a registered nurse.

    • Main Results:

    • Successful sedation was achieved in 85% (23/27) of patients, including 5 who previously failed chloral hydrate.
    • An overall acceptable EEG quality was obtained in 93% (25/27) of participants.
    • Minor, transient, and asymptomatic reductions in heart rate and blood pressure were observed in a small percentage of patients, requiring no intervention.

    Conclusions:

    • Clonidine is a safe, well-tolerated, and effective alternative for pediatric sedation in children with autism and PDD undergoing EEG.
    • Advantages include ease of administration, shorter sedation duration, no "drug effect" on EEGs, and a high success rate.
    • Clonidine facilitates essential diagnostic procedures for this vulnerable pediatric population.