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Study on frequency and predictors of dementia after ischemic stroke: the Chongqing stroke study

David H D Zhou1, John Y J Wang, Jingcheng Li

  • 12nd Dept. of Neurology, Daping Hospital, 3rd Military Medical University, Chongqing, China. zhouhuad@163.com

Journal of Neurology
|April 15, 2004
PubMed

Insights

Poststroke dementia affects about one-fourth of patients within three months of an ischemic stroke. Key predictors include advanced age, low education, prior stroke, and atrial fibrillation.

Area of Science:

  • Neurology
  • Geriatrics
  • Public Health

Background:

  • Ischemic stroke is a leading cause of long-term disability.
  • Dementia is a significant consequence of stroke, impacting quality of life.
  • Identifying risk factors for poststroke dementia is crucial for prevention and management.

Purpose of the Study:

  • To determine the frequency of dementia after ischemic stroke in older adults.
  • To identify independent predictors of poststroke dementia.

Main Methods:

  • A cohort of 434 hospitalized patients aged 55+ with acute ischemic stroke was studied.
  • Neuropsychological tests were administered at admission and 3 months post-stroke.
  • Logistic regression analysis was employed to identify dementia predictors.

Main Results:

  • The frequency of poststroke dementia was 27.2% at 3 months.
  • Significant predictors included older age, low educational level, everyday drinking, prior stroke, atrial fibrillation, dysphasia, and left carotid territory infarction.
  • Older age (OR 1.179), dysphasia (OR 5.873), and atrial fibrillation (OR 3.475) were strongly associated with poststroke dementia.

Conclusions:

  • Approximately one-fourth of ischemic stroke patients develop dementia within three months.
  • Independent predictors of poststroke dementia are age, low education, everyday drinking, prior stroke, dysphasia, atrial fibrillation, and left carotid territory infarction.
  • These findings highlight modifiable and non-modifiable risk factors for targeted interventions.
Abstract

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