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Related Experiment Videos

Comparison of screening approaches.

H A Tilson1, V C Moser

  • 1Neurotoxicology Division, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711.

Neurotoxicology
|January 1, 1992
PubMed
Summary
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Neurobehavioral screening in rodents.

Current protocols in toxicology·2010

Functional observational batteries (FOB) are widely used in animal toxicology to screen for neurotoxicity. These assessments evaluate neurobiological functions and help differentiate between neurotoxicants and non-neurotoxicants.

Area of Science:

  • Toxicology
  • Neuroscience
  • Animal models

Background:

  • Neurobehavioral techniques are crucial in animal toxicology for assessing neurobiological functions potentially impacted by chemical exposure in humans.
  • Screening for neurotoxicity often involves large-scale animal testing, with functional observational batteries (FOB) being a widely accepted method.

Purpose of the Study:

  • To describe the utility and scope of functional observational batteries (FOB) in animal toxicology for screening neurotoxic effects.
  • To highlight the role of FOB in assessing dose-response relationships and the characteristics of neurotoxicant effects.

Main Methods:

  • FOB evaluations in animals are analogous to human clinical neurological examinations, assessing behavioral and neurological signs.
  • These batteries typically evaluate neuromuscular, sensory, and autonomic functions, though cognitive functions are usually not included.

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  • FOB are often employed alongside other neurotoxicity measures like neuropathology or sensory evoked potentials.

    • Main Results:

    • FOB provide valuable data on dose-response, onset, duration, and persistence of neurotoxic effects.
    • These assessments can differentiate between neurotoxicants and non-neurotoxicants.
    • FOB can also help distinguish neurotoxicants with different mechanisms or sites of action.

    Conclusions:

    • Functional observational batteries are essential tools for screening neurotoxicity in animal studies.
    • FOB offer a comprehensive approach to evaluating a range of neurobiological functions and characterizing toxicant effects.
    • The data generated by FOB aid in understanding chemical-induced neurotoxicity and its specific characteristics.