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Related Experiment Videos

Menstrual cycle and ST height.

Susanne Endres1, Kenneth A Mayuga, Alessandro de Cristofaro

  • 1Division of Cardiology, Northwestern University Medical School, Chicago, Illinois, USA.

Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
|April 16, 2004
PubMed
Summary

ST height and QTc varied across menstrual cycle phases, especially after autonomic blockade. Female sex hormones may influence cardiac repolarization measures.

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Area of Science:

  • Cardiology
  • Reproductive Endocrinology

Background:

  • The influence of sex hormones and menstrual cycle phases on ST height remains unclear.
  • Understanding these variations is crucial for accurate ECG interpretation in women.

Purpose of the Study:

  • To investigate the effect of the menstrual cycle on ST height.
  • To determine if sex hormones modulate cardiac repolarization parameters.

Main Methods:

  • Analyzed ECGs from 22 healthy women across three menstrual cycle phases (menses, follicular, luteal).
  • Measured ST height at baseline and after double autonomic blockade (DAB).
  • Utilized repeated measures ANOVA for statistical analysis, with P < 0.05 considered significant.

Main Results:

Related Experiment Videos

  • No significant baseline differences in ST height, QTc, or T wave amplitude across menstrual phases.
  • After DAB, ST height (at 40 ms and J-Point/QRS) and QTc were significantly higher in the follicular phase compared to the luteal phase.
  • ST height differences at the J-Point were not statistically significant across phases.

    • Conclusions:

    • ST height and QTc exhibit variations across menstrual cycle phases, particularly after autonomic blockade.
    • Menstrual cycle-dependent fluctuations in female sex hormones likely modulate cardiac repolarization.