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Driven to autoimmunity: the nod mouse
Alena M Gallegos1, Michael J Bevan
1Howard Hughes Medical Institute and the Department of Immunology, University of Washington, Box 357370, Seattle, WA 98195, USA.
Cell
|April 16, 2004
Abstract:
In the lymphoid system, T cells respond to space or under-crowding by dividing to maintain their numbers. In this issue of Cell, evidence is provided that this homeostatic proliferation, coupled with excess production of a cytokine, IL-21, is a key factor in susceptibility to autoimmune diabetes.
